Estrone powder

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Estrone Description

Therapeutic estrone is a synthetic form of the natural estrogen estrone. Estrone diffuses through cell membranes and binds and subsequently activates nuclear estrogen receptors found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bones. The activated hormone receptor complex is transferred to the nucleus, where it binds to estrogen response elements on DNA and promotes the transcription of target genes related to the female reproductive system and secondary sexual characteristics. Estrone increases the liver synthesis of sex hormone binding globulin (SHBG), thyroid binding globulin (TBG) and other serum proteins, and inhibits the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the front. pituitary.
Uses
Estrone is a metabolite of 17β-Estradiol (E888000). During the metabolism, it is in rapid equilibrium with Estriol (E888960) and 17β-Estradiol (E888000) (1). Causes the feminization of male fish at human and animal waste sites (2).This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.